Accurate transcriptome-wide prediction of microRNA targets and small interfering RNA off-targets with MIRZA-G: Figure 2.
نویسندگان
چکیده
منابع مشابه
Accurate transcriptome-wide prediction of microRNA targets and small interfering RNA off-targets with MIRZA-G
Small interfering RNA (siRNA)-mediated knock-down is a widely used experimental approach to characterizing gene function. Although siRNAs are designed to guide the cleavage of perfectly complementary mRNA targets, acting similarly to microRNAs (miRNAs), siRNAs down-regulate the expression of hundreds of genes to which they have only partial complementarity. Prediction of these siRNA 'off-target...
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Small RNAs such as microRNAs (miRNAs) are important regulators of genes in many organisms (He and Hannon, 2004). They have also been implicated in a growing number of diseases (Dalmay and Edwards, 2006). MiRNAs are cause translational repression and potentially mRNA degradation by binding to the 3' Untranslated regions (3'UTRs) of their target genes (Giraldez et al., 2006). This binding event i...
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MicroRNA (miRNA)-guided target RNA expression is vital for a wide variety of biological processes in eukaryotes. Currently, miRBase (version 13) lists 142 and 353 miRNAs from Arabidopsis and rice (Oryza sativa), respectively. The integration of miRNAs in diverse biological networks relies upon the confirmation of their RNA targets. In contrast with the well-characterized miRNA targets that are ...
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ژورنال
عنوان ژورنال: Nucleic Acids Research
سال: 2015
ISSN: 0305-1048,1362-4962
DOI: 10.1093/nar/gkv924